Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999-2007 in Taiwan
Identifieur interne : 000199 ( Main/Exploration ); précédent : 000198; suivant : 000200Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999-2007 in Taiwan
Auteurs : Ya-Fang Wang [Taïwan] ; Chuan-Fa Chang [Taïwan] ; Huey-Pin Tsai [Taïwan] ; Chia-Yu Chi [Taïwan] ; Ih-Jen Su [Taïwan] ; Jen-Ren Wang [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2018.
Abstract
It is generally agreed that human influenza virus preferentially binds to α-2,6-linked sialic acid-containing receptors, and mutations that change the binding preference may alter virus infectivity and host tropism. Limited information is available on the glycan-binding specificity of epidemic influenza viruses. In this study, we systemically investigated the glycan-binding preferences of human influenza A(H3N2) viruses isolated from 1999 to 2007 in Taiwan using a high-throughput carbohydrate array. The binding patterns of 37 H3N2 viruses were classified into three groups with significant binding-pattern variations. The results showed that the carbohydrate-binding patterns of H3N2 varied over time. A phylogenetic analysis of the hemagglutinin gene also revealed progressive drift year to year. Of note, the viruses that caused large outbreaks in 1999 and 2003 showed glycan-binding preferences to both α-2,3 and α-2,6 sialylated glycans. Twenty amino acid substitutions were identified primarily at antigenic sites that might contribute to H3N2 virus evolution and the change in the glycan-binding patterns. This study provides not only a systematic analysis of the receptor-binding specificity of influenza clinical isolates but also information that could help to monitor the outbreak potential and virus evolution of influenza viruses.
Url:
DOI: 10.1371/journal.pone.0196727
PubMed: 29746492
PubMed Central: 5945028
Affiliations:
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Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Chi, Chia Yu" sort="Chi, Chia Yu" uniqKey="Chi C" first="Chia-Yu" last="Chi">Chia-Yu Chi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Pediatrics, National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Pathology, National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Pathology, National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>It is generally agreed that human influenza virus preferentially binds to α-2,6-linked sialic acid-containing receptors, and mutations that change the binding preference may alter virus infectivity and host tropism. Limited information is available on the glycan-binding specificity of epidemic influenza viruses. In this study, we systemically investigated the glycan-binding preferences of human influenza A(H3N2) viruses isolated from 1999 to 2007 in Taiwan using a high-throughput carbohydrate array. The binding patterns of 37 H3N2 viruses were classified into three groups with significant binding-pattern variations. The results showed that the carbohydrate-binding patterns of H3N2 varied over time. A phylogenetic analysis of the hemagglutinin gene also revealed progressive drift year to year. Of note, the viruses that caused large outbreaks in 1999 and 2003 showed glycan-binding preferences to both α-2,3 and α-2,6 sialylated glycans. Twenty amino acid substitutions were identified primarily at antigenic sites that might contribute to H3N2 virus evolution and the change in the glycan-binding patterns. This study provides not only a systematic analysis of the receptor-binding specificity of influenza clinical isolates but also information that could help to monitor the outbreak potential and virus evolution of influenza viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kobayashi, Y" uniqKey="Kobayashi Y">Y Kobayashi</name></author><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viswanathan, K" uniqKey="Viswanathan K">K Viswanathan</name></author><author><name sortKey="Koh, X" uniqKey="Koh X">X Koh</name></author><author><name sortKey="Chandrasekaran, A" uniqKey="Chandrasekaran A">A Chandrasekaran</name></author><author><name sortKey="Pappas, C" uniqKey="Pappas C">C Pappas</name></author><author><name sortKey="Raman, R" uniqKey="Raman R">R Raman</name></author><author><name sortKey="Srinivasan, A" uniqKey="Srinivasan A">A 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Webster</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Wang, Ya Fang" sort="Wang, Ya Fang" uniqKey="Wang Y" first="Ya-Fang" last="Wang">Ya-Fang Wang</name></noRegion><name sortKey="Chang, Chuan Fa" sort="Chang, Chuan Fa" uniqKey="Chang C" first="Chuan-Fa" last="Chang">Chuan-Fa Chang</name><name sortKey="Chang, Chuan Fa" sort="Chang, Chuan Fa" uniqKey="Chang C" first="Chuan-Fa" last="Chang">Chuan-Fa Chang</name><name sortKey="Chi, Chia Yu" sort="Chi, Chia Yu" uniqKey="Chi C" first="Chia-Yu" last="Chi">Chia-Yu Chi</name><name sortKey="Chi, Chia Yu" sort="Chi, Chia Yu" uniqKey="Chi C" first="Chia-Yu" last="Chi">Chia-Yu Chi</name><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><name sortKey="Tsai, Huey Pin" sort="Tsai, Huey Pin" uniqKey="Tsai H" first="Huey-Pin" last="Tsai">Huey-Pin Tsai</name><name sortKey="Tsai, Huey Pin" sort="Tsai, Huey Pin" uniqKey="Tsai H" first="Huey-Pin" last="Tsai">Huey-Pin Tsai</name><name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name><name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name><name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name><name sortKey="Wang, Jen Ren" sort="Wang, Jen Ren" uniqKey="Wang J" first="Jen-Ren" last="Wang">Jen-Ren Wang</name><name sortKey="Wang, Ya Fang" sort="Wang, Ya Fang" uniqKey="Wang Y" first="Ya-Fang" last="Wang">Ya-Fang Wang</name><name sortKey="Wang, Ya Fang" sort="Wang, Ya Fang" uniqKey="Wang Y" first="Ya-Fang" last="Wang">Ya-Fang Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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